Relationship between vitamin D status, rs2228570 vitamin D receptor polymorphism genotypes, and cholecalciferol supplementation in school-age children with COVID-19

Purpose - to study the features of vitamin D status and effect D3 supplementation on 25(OH)D in serum school-age children with COVID-19, taking into account genotype rs2228570 polymorphism receptor (VDR) gene. Materials methods. The pilot, prospective, open-label included 36 schoolchildren aged 9-16 who experienced asymptomatic (12 children) mild / moderate (24 COVID-19. In all were studied content blood its dynamics under influence 1000 IU per day for 12 weeks, genotypes frequency distribution alleles VDR gene (26 children). Results. Children COVID-19 characterized by normal values (32.682.12 ng/ml). underwent probably more (41.7%) likely have a state hypovitaminosis (27.362.12 ng/ml) fewer (58.3%) an optimal level than disease. 80.7% examined children, was determined gene, which includes G allele greater transcriptional activity receptor. Supplementation cholecalciferol day, regardless this increased supply tendency increase G. Conclusions. Vitamin deficiency can be considered as risk factor symptomatic course requires monitoring correction status, effectiveness Further studies role complex development severity will significantly expand understanding pathogenetic relationship, suggest predict personalized regimens. research carried out accordance principles Helsinki Declaration. protocol approved Local Ethics Committee participating institutions. informed consent patient obtained conducting studies. No conflict interests declared authors.